New way to create high-speed LCDs based on the use of modified nanomaterials

Modified “detonation nanodiamond” (MDND), graphene oxide (MGO) and nanoclay (MNC) were doped to nematic (NLCs) and ferroelectric liquid crystals (FLCs). The effect of modified nanomaterials on the physical and electro-optical properties of liquid crystals was investigated

ОПТИЧЕСКИЕ СВОЙСТВА КОМПЛЕКСОВ УЛЬТРАДИСПЕРСНЫХ АЛМАЗОВ ДЕТОНАЦИОННОГО СИНТЕЗА С ИНДОТРИКАРБОЦИАНИНОВЫМ КРАСИТЕЛЕМ

A method to create complexes of detonation nanodiamonds with molecules of an indotricarbocyanine dye was developed. The process of complex formation was shown to depend on the nanodiamond annealing conditions. Nanodiamonds that were vacuum annealed at 750oC display the most effective interaction with the dye molecules. Formation of the complexes was studied with the aid of optical spectroscopy in the visible and infrared regions.Разработан метод получения комплексов ультрадисперсных алмазов детонационного синтеза с молекулами индотрикарбоцианинового красителя. Показано, что на процесс комплексообразования влияют условия термической обработки наноалмазов. Наиболее эффективное взаимодействие с красителем проявляется для ультрадисперсных алмазов, отожженных в вакууме при 750оС. Процесс образования комплексов изучен методом оптической спектроскопии в видимой и инфракрасной областях

Каталитические системы для реакций кросс-сочетания на основе модифицированных ультрадисперсных алмазов

Methods for preparation of nanocomposites of modified detonation nanodiamonds (DND) with metallic palladium have been developed and their catalytic activity in the Suzuki-Miyaura cross-coupling reaction in various reaction media has been studied. Methods for the regeneration of palladium-containing nanocomposites from the reaction mixture have been developed. The high catalytic activity of nanocomposites is confirmed by kinetic analysis based on the results of chromatographic analysis of the reaction mixture and is comparable to the literature data about similar catalytic systems. Regenerated nanocomposites showed the retention of catalytic activity for 3 consecutive cross-coupling cycles on model systems.Разработаны методы получения нанокомпозитов модифицированного ультрадисперсного алмаза детонационного синтеза с металлическим палладием и изучена их каталитическая активность в реакции кросс-сочетания Сузуки-Мияуры в различных реакционных средах. Исследованы методики регенерации палладийсодержащих нанокомпозитов из реакционной смеси. Каталитическая активность нанокомпозитов подтверждена исследованием кинетики реакции кросс-сочетания хроматографическим анализом реакционной смеси и сопоставима с уже используемыми подобными катализаторами. Регенерированные нанокомпозиты показали сохранение каталитической активности для 3 последовательных циклов кросс-сочетания на модельных системах

Спектральные свойства индотрикарбоцианинового красителя в тканях экспериментальных животных

The paper presents the results of studies of the spectral properties of a photosensitizer based on indotricarbocyanine dye when accumulating in tissues of experimental animals. Using laser fluorescence spectroscopy, the in vivo and ex vivo fluorescence spectra of tissue-localized indotricarbocyanine dye were obtained for different time counts after intravenous administration. The profile of the pharmacokinetics of its accumulation and withdrawal was determined from the change in the intensity of fluorescence in the tumor and healthy muscle tissues of the photosensitizer. A monotonic deformation of its fluorescence spectrum was revealed in the tissues of tumor nodes and muscles of the thigh when registered through the skin over time after intravenous administration. The achievement of the maximum accumulation of the photosensitizer in the tumor correlates with the stabilization of the shape of its in vivo fluorescence spectrum. Thus, the maximum shift can be used as a diagnostic indicator of the maximum accumulation of indotricarbocyanine photosensitizer in the tumor tissues. The results were confirmed for two groups of animals: the first one – black mice of the C57Bl/6 line with an inoculated tumor of Clone M3 melanoma, the second – white mice of the ICR line with an inoculated tumor of Ehrlich ascites carcinoma. The analysis of the shape of the fluorescence spectrum of the photosensitizer during registration through the skin for animals with different colors has been carried out.В работе приведены результаты исследований спектральных свойств фотосенсибилизатора на основе индотрикарбоцианинового красителя при накоплении в тканях экспериментальных животных. С помощью лазерной флуоресцентной спектроскопии получены спектры флуоресценции in vivo и ex vivo локализованного в тканях индотрикарбоцианинового красителя для разных временных отсчетов после внутривенного введения. По изменению интенсивности флуоресценции в опухолевой и здоровой мышечной тканях фотосенсибилизатора определен профиль фармакокинетики его накопления и вывода. Выявлена монотонная деформация его спектра флуоресценции в тканях опухолевых узлов и мышц бедра при регистрации через кожу с течением времени после внутривенного введения. Достижение максимального накопления фотосенсибилизатора в опухолевом узле коррелирует со стабилизацией формы его спектра флуоресценции in vivo. При этом смещение максимума может использоваться в качестве диагностического индикатора максимального накопления индотрикарбоцианинового фотосенсибилизатора в тканях опухолевых узлов. Результаты подтверждены для двух групп животных: первая – черные мыши линии C57Bl/6 с перевитой опухолью меланомы Clone M3, вторая – белые мыши линии ICR с перевитой опухолью асцитной карциномы Эрлиха. Проведен анализ формы спектра флуоресценции фотосенсибилизатора при регистрации через кожу для животных с разной окраской

Optical properties of the complexes of detonation nanodiamonds with an indotricarbocyanine dye

A method to create complexes of detonation nanodiamonds with molecules of an indotricarbocyanine dye was developed. The process of complex formation was shown to depend on the nanodiamond annealing conditions. Nanodiamonds that were vacuum annealed at 750oC display the most effective interaction with the dye molecules. Formation of the complexes was studied with the aid of optical spectroscopy in the visible and infrared regions

Optical properties of the complexes of detonation nanodiamonds with an indotricarbocyanine dye

Разработан метод получения комплексов ультрадисперсных алмазов детонационного синтеза с молекулами индотрикарбоцианинового красителя. Показано, что на процесс комплексообразования влияют условия термической обработки наноалмазов. Наиболее эффективное взаимодействие с красителем проявляется для ультрадисперсных алмазов, отожженных в вакууме при 750 оС. Процесс образования комплексов изучен методом оптической спектроскопии в видимой и инфракрасной областях. A method to create complexes of detonation nanodiamonds with molecules of an indotricarbocyanine dye was developed. The process of complex formation was shown to depend on the nanodiamond annealing conditions. Nanodiamonds that were vacuum annealed at 750 oC display the most effective interaction with the dye molecules. Formation of the complexes was studied with the aid of optical spectroscopy in the visible and infrared regions

Indotricarbocyanine dyes relevant for photodynamic therapy and their radicals: Substituent effects studied by optical and electrochemical methods

Photodynamic therapy is an effective and minimally invasive treatment method for cancer. A deeper under- standing of the photocytotoxicity mechanism of cyanine dyes is necessary for the development of more efficient photosensitizers. We combine electrochemistry, optical and ESR spectroscopy, and quantum chemical calcula- tions to study indotricarbocyanine dyes relevant for photodynamic therapy. The incorporation of 4-meso-chloride and a 3,5-o-phenylene bridge into the polymethine chain results in a hypsochromic shift of the absorption spectrum by ca. 30 nm and in a downward shift of the frontier orbitals energy levels by 0.1–0.3 eV. In addition, such substitution imparts stability to the electrogenerated radical dications of the dyes. The presence of 4-meso- chloride and a 3,5-trimethylene bridge in the polymethine chain causes the absorption spectrum to shift bath- ochromically by almost 40 nm and the HOMO–LUMO energy gap to decrease by ca. 0.1 eV. The radical dication of the dye with such substitution is particularly stable and exhibits improved electron delocalization. The radical dication of the dye with an unsubstituted polymethine chain is unstable due to its propensity to form dimers. The substituents at the nitrogen atoms are shown to have almost no influence on the optical and electrochemical properties of the indotricarbocyanine dyes. The radical dications of the dyes with an o-phenylene bridge can oxidize bromide ions, unlike the radical dications of the dyes with an unsubstituted polymethine chain or with a trimethylene bridge. The reported data can be used to develop new indotricarbocyanine dyes with desired characteristics

Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics

The synthesis methods for the indotricarbocyanine dyes covalently bonded to polyethylene glycols with varying degrees of polymerization have been developed. New indotricarbocyanine was synthesized in one step using the Mukayama reagent in polyethylene glycol with cesium fluoride as a basic catalyst. In vivo investigation of the phototherapeutic dye activity has shown selective recognition of malignant tissues, where accumulation of the dye was 4–5 times higher than in normal tissues. The necrotic area after local photoirradiation at the effective energy fluence 180 J/cm2, l = 780 nm was observed to a depth of 2.5 cm making the synthesized dyes very promising for further pharmaceutic researc

Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics

The synthesis methods for the indotricarbocyanine dyes covalently bonded to polyethylene glycols with varying degrees of polymerization have been developed. New indotricarbocyanine was synthesized in one step using the Mukayama reagent in polyethylene glycol with cesium fluoride as a basic catalyst. In vivo investigation of the phototherapeutic dye activity has shown selective recognition of malignant tissues, where accumulation of the dye was 4–5 times higher than in normal tissues. The necrotic area after local photoirradiation at the effective energy fluence 180 J/cm2, l = 780 nm was observed to a depth of 2.5 cm making the synthesized dyes very promising for further pharmaceutic researc

Spectral and luminescent properties and morphology of self-assembled nanostructures of an indotricarbocyanine dye

Spectral and luminescent properties of an indotricarbocyanine dye are studied in solutions and after deposition on quartz or silicon substrates. It is found that the dye molecules self-assemble in aqueous EtOH solutions to form H*-aggregates. The absorption band of the H*-aggregates shows a hypsochromic shift of 192 nm (5291 cm–1) relative to the absorption maximum of dye monomers (706 nm) and has a full width at half maximum of 21 nm (797 cm–1). The morphology of the H*-aggregates of the indotricarbocyanine dye is studied for the fi rst time. It is found that the aggregates are rod-like species ~10 nm high, 100 nm wide, and several micrometers long. H-aggregates with a fl uorescence maximum at 560 nm and Stokes shift of 325 cm–1 in addition to non-fl uorescent H*-aggregates form in aqueous EtOH solutions and are nanoparticles with a height of 1–3 nm and lateral dimensions of ~100 nm